currentsinbiology: The rebound acid that occurs when PPI-withdrawing also makes it very difficult fo
currentsinbiology:The rebound acid that occurs when PPI-withdrawing also makes it very difficult for patients to stop taking them - but it can be done with patience.Study Finds Growing Reason to Be Wary of Some Reflux DrugsSince their introduction in 1990, the drugs collectively known as proton pump inhibitors (common brand names: Nexium, Prevacid, Prilosec) have become among the most frequently prescribed in the country. They are also available over the counter. They suppress stomach acid more effectively than a previous class of drugs called H2 blockers (Zantac, Tagamet, Pepcid).They have also given users reason to be wary. In recent years, scores of studies have reported associations between prescription P.P.I. use and an array of health problems, including bone fractures, low magnesium levels, kidney injuries and possibly cardiovascular drug interactions.They are also linked to infections, like the stubborn Clostridium difficile and pneumonia. Reducing the acidity of the stomach, researchers believe, allows bacteria to thrive and then spread to other organs like the lungs and intestines.The latest findings, published last month in JAMA Internal Medicine, point to increased risk of chronic kidney disease among users, which is particularly worrisome.There’s also a study that found a correlation between PPI usage and premature death. So I’ve switched back to the definitely less effective H2s for my GERD, which means my asthma is worse, since any amount of reflux aggravates asthma. Now I’m super $*(&#ing tired all the time due to the asthma, OR I can have chronic UTIs/be cranky and further increase my already considerable risk for osteoporosis when I take my most useful asthma meds which cost over $300 a pop anyway. There’s a non-medication alternative for my asthma but it isn’t approved by the FDA, is expensive, and of course parasites come with their own side effects. Bodies are great. -- source link
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