These are JawsII cells – immature dendritic cells that were derived from the bone marrow o
These are JawsII cells – immature dendritic cells that were derived from the bone marrow of mice of a specific genetic background*, and subsequently immortalized for use in continuous cell culture. Like immature dendritic cells in vivo, cells from the JawsII line can become mature dendritic cells, which have a characteristic dendrite-like morphology, upon stimulation with antigen. Dendritic cells, along with macrophages and B cells, are antigen-presenting cells. Immature dendritic cells, which are visually very similar to the cells pictured above, capture antigens from their surroundings via mechanisms such as phagocytosis. then process these antigens and present them on their surfaces in the context of MHC class II. Acquisition and presentation of antigen leads to the migration of dendritic cells to the lymph nodes, where they present antigen to (and stimulate) T and B cells. Dendritic cells can also be derived from either immortalized monocyte cell lines or primary monocytes derived from blood. In a lab setting, monocyte differentiation into immature dendritic cells is induced by GM-CSF and IL-4 *; stimulating the immature dendritic cells with potent mediators of inflammation like TNF-alpha will induce their maturation into dendrite-bearing cells. -- source link
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