This one probably needs a bit of explanation. Basically, this is a diagram of the three types of opi
This one probably needs a bit of explanation. Basically, this is a diagram of the three types of opioid receptor, mu (MOP), kappa (KOP) and delta (DOP). MOP = upper right corner, activation of the receptor opens potassium channels. This decreases the spread of activity so that calcium channels don’t open, thus decreasing the influx of calcium into the cell and reducing intracellular calcium. KOP = lower left corner, activation of KOP causes calcium channels to close, causing decreased intracellular calcium. DOP = upper left corner, inactivates adenylyl cyclase, resulting in decreased cAMP, which causes decreased intracellular calcium levels. The decreased intracellular calcium causes decreased release of neurotransmitter vesicles (the blobs in the lower right corner of the cell), causing decreased activity of the neurone (which will generally be a pain neurone but can also be in the gut, hence why morphine causes constipation), etc. -- source link
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