New model describes phase separation that spoils antibody solutionsA new mathematical model describe
New model describes phase separation that spoils antibody solutionsA new mathematical model describes how highly concentrated antibody solutions separate into different phases, similar to an oil and water mixture. This separation can reduce the stability and shelf-life of some drugs that use monoclonal antibodies, including some used to treat autoimmune diseases and cancer. A team of scientists from Penn State and MedImmune, LLC (now AstraZeneca) investigated the thermodynamics and kinetics, the relationships between temperature, energy, and the rates of chemical reactions, of the phenomenon using an innovative method that allows for the rapid study of multiple samples at once. A paper describing their model appears July 22, 2019, in the journal Proceedings of the National Academy of Sciences.Many drugs today are stored as solids and dissolved in IV bags for delivery to patients, but the pharmaceutical industry has been moving toward drugs that can be stored as liquids and given via a shot. Some of these drug solutions, like those used to treat autoimmune diseases and some cancers, contain high concentrations of monoclonal antibodies—proteins that attach to foreign substances in the body, like bacteria and viruses, flagging them for destruction by the patient’s immune system.Read more. -- source link
Tumblr Blog : materialsscienceandengineering.tumblr.com
#materials science#science#phases#biomaterials#medical technology#penn state#proteins#liquids