Connection between childhood adversity, psychiatric disorders seen at cellular level In a new study
Connection between childhood adversity, psychiatric disorders seen at cellular level In a new study published online in Biological Psychiatry on January 16, 2015, researchers from Butler Hospital identify an association between biological changes on the cellular level and both childhood adversity and psychiatric disorders. These changes in the form of telomere shortening and alterations of mitochondrial DNA (mtDNA), are important in the aging process, and this new research provides evidence that psychosocial factors–specifically childhood adversity and psychiatric disorders– may also influence these cellular changes and could lead to accelerated aging. Mitochondria convert molecules from food into energy that can be used by cells and also play a key role in cellular growth, signaling, and death. Telomere shortening is also a measure of advanced cellular aging. Recent studies have examined the possible connection between mitochondria and psychiatric disorders, but the research is very limited, and no prior work has examined the relationship of mitochondrial DNA to psychosocial stress. “We are interested in these relationships because there is now clear evidence that stress exposure and psychiatric conditions are associated with inflammation and health conditions like diabetes and heart disease. Identifying the changes that occur at a cellular level due to these psychosocial factors allows us to understand the causes of these poor health conditions and possibly the overall aging process.” said Audrey Tyrka, MD, PhD, Director of the Laboratory for Clinical and Translational Neuroscience at Butler Hospital and Associate Professor of Psychiatry and Human Behavior at Brown University. Audrey R. Tyrka, Stephanie H. Parade, Lawrence H. Price, Hung-Teh Kao, Barbara Porton, Noah S. Philip, Emma S. Welch, Linda L. Carpenter. Alterations of Mitochondrial DNA Copy Number and Telomere Length with Early Adversity and Psychopathology. Biological Psychiatry, 2015; DOI: 10.1016/j.biopsych.2014.12.025 Results of the study show childhood adversity and lifetime psychopathology were each associated with shorter telomeres and higher mtDNA content. Credit: © Phils Photography / Fotolia -- source link
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