usmle1mikmonics:diseasesinthreewords:Poeta uruguayo, Mauricio Saravia. Photo from www.lukeford.n
usmle1mikmonics: diseasesinthreewords: Poeta uruguayo, Mauricio Saravia. Photo from www.lukeford.net posted on Wikimedia Commons in 2008. Another notabe case in a teenager from Haiti. The three words of McCune-Albright disease: The most famous (mouthfull) words of the condition: Polyostotic Fibrous Dysplasia. What that means is that the bone will grow tumor-like fibrous (scar) tissue instead of the normal medullary (bone marrow) bone tissue. Irregular Bony trabeculae That will cause the deformities that make the disease famous. It’s caused by mutation in the gene GNAS1 and affects mostly the extremities. Not cancerous. Mosaic G protein signaling mutation Premature puberty in girls. It can affect boys as well, but the question stem in exams tend to report female cases, like a 2-year-old with menstrual bleeding. Early puberty is one of the many endocrine problems of these patients and a favorite to put in exams. Other problems include over-reactivity of the thyroid, pituitary and adrenal glands (hyperthyroidism, acromegally and hypercortisolism). And, of course, Café-au-lait spots. The interesting feature is the tendency for the lesions to not cross the body’s midline. McCune AlBrightC = Cafe au lait spotsE = Early pubertyAB = Abnormal Bones (Fibrous Dysplasia) -- source link
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