Till not so long ago one of the most utilized agents to treat ashthma crysis was one that belong to
Till not so long ago one of the most utilized agents to treat ashthma crysis was one that belong to the “beta-2 agonists” class. The name means that they are able to stimulate that specific cellular receptor: the adrenergic receptor type beta-2.Alpha and beta receptors activation is part of the sympathetic nervous system reaction in order to generate the famous fight/flight response, essential to survive. Those receptors activation works like an accelerator for the body by increasing the diameter of the airways making air more available; by increasing heart and breathing rate to deliver more oxygen through the blood to the muscles and other organs; by increasing the diameter of the pupils to enhance vision; by mobilizing the energy reserves and more. Everything in order to prepare you to start a fight or to fly from it. The beta-2 receptors can be found mainly in the airways and their pharmacological activation leads to airways relaxation, increases the airflow and releives the symptoms of ashthma. The problem is that expecially the first drugs of this type utilized in the past were not so specific and were able to activate also the adrenergic receptors type beta-1 that resides mainly in the heart stimulating them. Oxygen is necessary for any cell type in order to make a compound called ATP that in muscles enables the movement by its consumption and the heart is not an exception. It’s not hard to imagine what can happen in a heart when the amount of oxigen is low as a consequence of the airways blockage during an ashthma crysis and the workload is increased due to an activation of the beta-1 receptors… in some cases results have been catastrophic. Nowadays the new drugs of that type are more specific and other completely different therapeutical approaches are available too. -- source link
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